The cross is an emblem of service and care; it stands for the U.S. Army Medical Department Activity (MEDDAC).  The maroon saltire, embodies protection and devotion to the preservatrion of life. The flaming black torch is from the shoulder sleeve insignia of the Army Aviation Center and the Army Aviation School.  The Center and School, situated at Fort Novosel, Alabama, are served by the Medical Department Activity.  The serpent entwining the stem of the torch simulates the Staff of Aesculapius, mythological god of medicine.  The wings refer to flight training and with the torch and serpent allude to area medical services and the health protection of Fort Novosel.  The lozenge represents a diamond, emblematic of harmony and vitality; orange symbolizes health and vigor.  Maroon and white are the colors used for organizations of the Army Medical Department.

The distinctive unit insignia was originally approved for the Lyster Army Hospital on 9 July 1970.  It was redesignated for the U.S. Army Medical Department Activity, Fort Rucker on 21 September 1973.  The insignia was redesignated for the U.S. Army Aeromedical Center, Fort Rucker, on 22 July 1974. The insignia was redesignated for the U.S. Army Medical Department Activity, Fort Novosel with symbolism revised on 16 June 2023.